From pathophysiology to precision medicine for Parkinson’s disease


Parkinson's disease is a common, complex and disabling neurodegenerative disease with an increasing personal, societal and financial burden. The PD patients population is highly heterogenous, with multiple patterns of disease progression. The underlying biology of the disease, the phenotypic variation and the genetic risk profile of patients must be explored for the implementation of personalized therapeutic interventions.

In 2018, the NS-PARK netork was selected in the exceptionnal call for proposals of the France Parkinson association to complement the NS-PARK cohort with a biocollection and associate a patient stratification project. The project relies on the clinical cohort sponsored by Inserm, on the expertise of the NS-PARK clinical research network, the Parkinson's disease genetics teams (JC Corvol, ICM), epidemiology teams (F Tubach, Pitié Salpêtrière hospital) and artificial intelligence team (S Durrleman, ICM), two preclinical teams (D Devos, Lille; W Meissner ad E Bezard,  Bordeaux) and associates two foreign cohorts for validation (D Grosset, UK; O Monchy, Canada).

The PRECISE-PD project plans to continue the effort of collecting longitudinal clinical data from the cohort and to complete them with: a biobank; data quality control and data management; developement of models for the analysis of disease progression integrating clinical and genetic data; implementation of a pipeline for imaging data; validation of obtained results in independent cohorts (UK and Canada partners).


The main objective of the PRECISE-PD project is to propose a model of Parkinson's disease progression based on the pathophysiological mechanisms.

Data life cycle

The processing of the data collected in the NS-PARK cohort is under the responsibility of Inserm, the sponsor of this study. Within the PRECISE-PD project, the life cycle of the data is unchanged.

Patient Information:

If you are a participant in the NS-PARK cohort and wish to obtain additional information on the processing and use of your data, please see the dedicated section Your Data