In order to deepen our knowledge of Parkinson's disease, the NS-PARK/F-CRIN network set up a cohort1 in 2016 that includes all patients with this pathology or a related disorder followed up in Parkinson Experts Centers in France. Current research on Parkinson's disease focuses on understanding the different progression profiles of the disease, in order to eventually apply personalized medicine, adapted to each patient. The challenge is to identify subgroups of patients sharing common disease course and to understand the associated molecular mechanisms.
The challenge is twofold:
i) to better manage patients medically by developing predictive and personalized medicine,
ii) to promote the developement of precision therapies by targeting homogenous populations in terms of the involved pathophysiological mechanisms.
The success of the NS-PARK cohort is based on a large-scake collaborative effort and a qualitative commitment, thanks to which the NS-PARK/F-CRIN network can provide a homogenous longitudinal data set2 to the scientific community that can be used to solve scientific questions.
Objective of the cohort: The analysis of the collected data, clinical but also biological and imaging, will make it possible to describe the natural history of Parkinson's disease, its progression and the response to treatment.
Regulatory framework: the NS-PARK cohort received the agreement from the Comité de Protection des Personnes Ile de France 1 (Ethics committee) on 19/06/2020 and the autorization of the CNIL (French data protection authority) on 12/02/2021.
1Cohorts are composed of a group of people who are individually followed over time. Their purpose is to identify the occurrence of health events of interest and the related risk or protective factors. Cohorts are one of the reference instrument for epidemiological and public health research. https://www.inserm.fr/recherche-inserm/recherche-en-sante-publique/cohortes
2A longitudinal study observes a phenomenon or a population repeatedly over time to analyze the evolution of an event (as opposed to a cross-sectional study which focuses on a specific moment in time).