In order to implement the collection of data and samples for the cohort, various technical tools are used by the research teams. Only authorized study staff have access to the data and samples collected.
Online data entry database
Data collected during the inclusion in the cohort and follow-up visits are recorded by research professionals through secure access to an electronic case repart form (REDCapTM eCRF1; https://www.project-redcap.org). All participating centers have the same interface, for a standardized and homogenous data collection. Data extraction from the system, for analysis, is carried out in accordance with regulatory requirements in terms of confidentiality.
Biological Resource Center
Biological samples collected as part of the cohort are sent under coded labeling to the DNA & Cell Bank in the Brain and Spine Institute (Institut du Cerveau et de la Moelle - ICM) at the Pitié Salpêtrière Hospital, in Paris (https://institutducerveau-icm.org/en/biological-resource-center/). This centralization will allow standardized storage and processing of samples in a certified quality environment (AFNOR NF S 96900).
Multicenter neuroimaging platform
The brain images collected in the cohort are centralized at the Centre d’Acquisition et de Traitement d’Images (CATI, https://cati-neuroimaging.com) in Paris, which is responsible for the harmonization (monitoring, standardization) of imaging data of the project.
1An electronic Case Report Form is used to collect online data useful for the research