Biology part of the cohort

Implementation

 

Optionnal biological samples are proposed to participants included in the cohort (see the table below).

 

Biological residuals1 from care or other research projects can also be collected for analysis in the NS-PARK cohort.

 

The collected samples are transferred to the Biological Resource Center of the ICM (Paris). Only authorized staff have access to the collected samples. The analyses planned on these samples are described in the table below.

 

 

 

Analysis

 

Origin of the sample

Type

Analysis

Objectives

Proposed in the cohort

(Optionnal)

Blood, saliva

Plasma, serum

DNA, RNA

Metabolomic markers

Biomarkers

Susceptibility factors

Protective factors

Modifying genes

Mutations

Skin biopsy

Cell culture

Biomarkers
Transcriptome

Biomarkers associated to the Parkinson's disease or its progression

Urine

Biomarkers
Autophosphorylated LRRK2

Exosome

Retrieved if performed in care or other research study

Cerebrospinal fluid

a-synuclein, tau

Exosome
Other biomarkers

Salivary gland

a-synuclein

 

1The biological residual is the remaining volume of a biological sample originally collected as part of the patient's routine follow-up or from another study in which the patient participated.

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